The immune response is a tightly regulated process, in which any breach of this strict regulation can lead to pathological …
Continue reading
Articles
In Focus: Piezo Channels
Mechanical stimulus is the driving force for numerous physiological processes including pain sensation, hearing, and blood pressure regulation2. Piezo1 and …
Continue readingIn Focus: 5-HT3 Receptors
5-HT (5-hydroxytryptamine, serotonin) is one of the most versatile neurotransmitters. It signals in part through 5-HT3 receptors which belong to …
Continue readingKV4 Channels Link Cognitive Decline and Cardiac Dysfunction During Aging
Voltage-dependent potassium channels (KV4) are expressed in the brain and the heart where they regulate cognitive function and cardiac output. …
Continue readingTTA-P2 and TTA-A2: Specific and Potent CaV3 Channel Blockers
Genes encoding T-type CaV channels yield three pore-forming subunits: CaV3.1, CaV3.2 and CaV3.3 which give rise to currents that are …
Continue readingNaV Channels and Pain
The role of NaV Channels in several types of pain opens a gateway for the development of specific sodium-channel inhibiting …
Continue readingNMDA Receptor Dynamics Dictate Neuronal Plasticity and Function
N-Methyl-D-Aspartate Receptor (NMDAR) are ubiquitously expressed along the central nervous system and are instrumental to various physiological processes such as …
Continue readingGuide to Venom Toxins as Ion Channel Modulators
Venomous creatures deploy a wide array of proteins and peptides, active on a spectrum of targets, for prey immobilization. These …
Continue readingDecoding the L-Type Ca2+ Signal: A Story of Transcription Regulation
L-type voltage-sensitive Ca2+ channels (CaV) on the plasma membrane of diverse cell types play a fundamental role in Ca2+ signaling …
Continue readingFluorescently-Labeled Toxins: Novel Tools for Working with Live Cells
Venom proteins and peptides have emerged as invaluable tools for research, drug discovery and drug development due to their small …
Continue reading