It has been more than thirty years since the discovery of a small tetradecapeptide that was able to inhibit the …
Continue readingGPCRs
The Hype on the Endothelin Signaling System
Over the past two decades, research in the endothelin signaling system has been quite intensive since they are profoundly involved …
By Melanie Grably, Ph.D.
Continue reading Muscarinic Receptor Family
The muscarinic receptors belong to the G-protein coupled receptors (GPCR) family. In mammals, at least five different muscarinic acetylcholine receptor …
By Dovrat Brass, Ph.D., B. Pharm.
Continue reading The Brains on Adenosine Receptors
Adenosine is a small ubiquitous molecule known for its role as an energy and genetic code building block. Adenosine also …
By Melanie Grably, Ph.D., Scientific Editor, Marketing Division
Continue reading Controversial Feelings about Dopamine Receptors
Dopamine (DA) is a neurotransmitter involved in the control of several crucial cerebral and peripheral functions. It plays a role …
By Dovrat Brass, Ph.D., B.Pharm., Director, Protein Group
Continue reading To Fight or to Flee from Adrenoceptors
Adrenoceptors are seven transmembrane proteins belonging to the superfamily of G-protein coupled receptors (GPCRs). They respond to the endogenous ligands …
By Melanie Grably, Ph.D., Scientific Editor, Marketing Division
Continue reading Endothelins and Urotensin II
Endothelins (ET-1,2,3) and Urotensin II are peptides that are considered to be very powerful vasoconstrictive substances. In humans, endothelins mediate …
By Ofra Gohar, Ph.D.
Continue reading Melanocortin Receptors in the Kidney and Nervous System
The five melanocortin receptors are members of the seven-transmembrane domain, G-protein coupled receptor (GPCR) superfamily. Melanocortins, the ligands of the …
By Amit Reif, M.Sc., Melanie Grably, Ph.D.
Continue reading In Focus: Formyl Peptide Receptors
Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in …
By Alomone Labs
Continue reading Ion Channel Modulation by G-Protein Coupled Receptors
The G-protein coupled receptors (GPCRs) are the largest and most versatile protein family in the mammalian genome. They interact with …
By Ofra Gohar, Ph.D.
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