TRP channels show diverse biophysical properties and gating mechanisms and were found to play an important role in sensory physiology, …
Continue readingIon Channels
Mainstream- Fringe- and Patho- Physiology of Voltage Dependent Na+ (NaV) Channels
Voltage gated Na+ (NaV) channels mediate action potential genesis and propagation in most excitable cells. Other roles played by NaV …
By Alon Meir, Ph.D.
Continue reading Ca2+-Dependent K+ (KCa) Channels: At the Crossroads of Cell Metabolism
K+ channels are the largest and most diverse superfamily of ion channels. They are ubiquitously expressed in both excitatory and …
By Noemí Bronstein, Ph.D.
Continue reading Targeting Ion Channels in Living Cells
During the last few years there has been an increased focus on ion channel-related research in tissues and cells other …
By Noemí Bronstein, Ph.D.
Continue reading Voltage Dependent Ca2+ (CaV) Channels
In many physiological systems, voltage dependent Ca2+ (CaV) channels are the molecular link between cellular membrane potential and intracellular Ca2+ …
By Alon Meir, Ph.D.
Continue reading Ion Channels in Endocrine Pancreatic Cells and their Role in Diabetes
Maintaining glucose homeostasis is an important factor in mammalian physiology, and is controlled to a large extent by the pancreas. …
By Ronit Cherki, Ph.D., Lisandro Luques, Yossi Anis, Ph.D., and Alon Meir, Ph.D.
Continue reading The ether-a-go-go Related Gene (erg) Voltage-Gated K+ Channels: A Common Structure With Uncommon Characteristics
The erg or KV11 (according to the new nomenclature) is a subfamily of the voltage dependent K+ channel superfamily and includes …
By Noemi Bronstein-Sitton, Ph.D.
Continue reading The Sexiest Channels Alive: The Role of Ion Channels in Penile Erection
Penile erection is a spinal reflex that involves integration of tactile, olfactory, visual and auditory inputs in the central nervous …
By Noemi Bronstein-Sitton, Ph.D.
Continue reading Ion Channels and Oxygen Sensing in the Carotid Body
Oxygen is an absolute requirement of all mammalian cells. Practically every cell is able to sense a decrease in oxygen …
By Noemí Bronstein, Ph.D.
Continue reading The Role of Ion Channels in Neurodegeneration
Neurodegenerative diseases take an enormous toll on society as well as on individuals. Very limited treatments for these diseases exist, …
By Phyllis Dan, Ph.D.
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