The transient receptor potential (TRP) superfamily, one of the largest ion channel families, consists of a diverse group of proteins. …
Continue readingIon Channels
K+ Channels in Cardiomyocytes
The contribution and importance of K+ channels to the normal activity of the heart is best exemplified by disturbances in …
By Alon Meir, Ph.D.
Continue reading The Involvement of Ion Channels in Cell Proliferation
The control of cell proliferation involves diverse signaling pathways, growth factors, and receptors. The involvement of ion channels in this …
By Phyllis Dan, Ph.D.
Continue reading Tripping Over TRPC
The canonical transient receptor potential channels (TRPCs) are non-selective cation channels that are expressed in a variety of multicellular organisms …
By Melanie Grably, Ph.D.
Continue reading Ionotrophic ATP (P2X) Receptors
P2X receptors are surface membrane ligand-gated channel proteins that rapidly translate extracellular ATP elevation into an intracellular Ca2+ surge which …
By Alon Meir, Ph.D.
Continue reading Characterization of Neuronal K+ Channels
A wide variety of K+ currents recorded in neurons can be distinguished according to their functional and pharmacological properties. The …
By Phyllis Dan, Ph.D.
Continue reading Voltage-Gated Ca2+ Channels in the Cardiovascular System
Voltage-gated Ca2+ channels play a pivotal role in the regulation of a wide range of cellular processes, including membrane excitability, …
By Etai Shpigel, Ph.D. and Yossi Anis, Ph.D.
Continue reading Aquaporins: the Waterways of Nature
The importance of the Aquaporin water channels was underscored by awarding the 2003 Nobel Prize in Chemistry to Peter Agre …
By Ofra Gohar, Ph.D., Co-Director, Antibody Group
Continue reading Voltage-Gated Na+ Channels in the CNS
Voltage-gated Na+ channels are membrane proteins that are essential for the generation and propagation of action potentials in excitable tissues, …
By Ronit Cherki, Ph.D., Director, Electrophysiology Group
Continue reading Tickling the Heart and the Nervous System with the Funny Current
Since their discovery in sinoatrial node cells and neurons in the late 1970s and early 1980s, Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) …
By Dovrat Brass, Ph.D. and Melanie Grably, Ph.D.
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