N-Methyl-D-Aspartate Receptor (NMDAR) are ubiquitously expressed along the central nervous system and are instrumental to various physiological processes such as …
Continue readingNeuroscience
NGF: One Molecule, Multiple Functions
Nerve Growth Factor (NGF) is one of the founding and best-characterized members of the neurotrophin family. This family comprises a …
By Dovrat Brass, Ph.D., B.Pharm
Continue reading BDNF – Second Best?
Brain Derived Neurotrophic Factor (BDNF) is the second best characterized neurotrophin (following NGF) and acts as a key contributor to …
By Alon Meir, Ph.D.
Continue reading Live or Let Die in Neuroscience: The Story of the Proneurotrophins
Although it has been more than forty years since the neurotrophins were first discovered we are only now starting to …
By Phyllis Dan, Ph.D.
Continue reading GABA (B) Receptors: an Example of Subtle Modulations in a Neurotransmitter System
The “GABAergic” system is the main inhibitory network in the central nervous system and as such influences almost every aspect …
By Alon Meir, Ph.D., CSO & R&D Manager
Continue reading The Brains on Adenosine Receptors
Adenosine is a small ubiquitous molecule known for its role as an energy and genetic code building block. Adenosine also …
By Melanie Grably, Ph.D., Scientific Editor, Marketing Division
Continue reading Controversial Feelings about Dopamine Receptors
Dopamine (DA) is a neurotransmitter involved in the control of several crucial cerebral and peripheral functions. It plays a role …
By Dovrat Brass, Ph.D., B.Pharm., Director, Protein Group
Continue reading Role of Voltage-Gated K+ Channels in the Pathophysiology of Spinal Cord Injury
Spinal cord injury (SCI) is a devastating condition afflicting over 13,000 people annually in North America and is an important cause of mortality and neurological morbidity1.
Although early pharmacological intervention after SCI with methylprednisolone2,3 or GM-1 ganglioside4 results in modest neurological improvement, the overall impact of these treatments remains minimal. Therefore, novel therapeutic approaches are required to improve the neurological outcome of these patients.
By Raad Nashmi, Ph.D. and Michael G. Fehlings, M.D., Ph.D.
Continue reading Muscarinic Receptors
Acetylcholine, the major neurotransmitter in the central and the peripheral nervous system, can act through two kinds of receptors1: ionotropic …
By Yona Bismuth, M.Sc.
Continue reading The Ionotropic GABAA Receptor
GABA (g-aminobutiric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.1
The GABA transmitter interacts with two major types of receptors: ionotropic GABAA (GABAAR) and the metabotropic GABAB receptors. The GABAAR belong to the ligand-gated ion channel superfamily.2
By Ofra Gohar, Ph.D.
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