A wide variety of K+ currents recorded in neurons can be distinguished according to their functional and pharmacological properties. The …
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Voltage-Gated Ca2+ Channels in the Cardiovascular System
Voltage-gated Ca2+ channels play a pivotal role in the regulation of a wide range of cellular processes, including membrane excitability, …
Continue readingα-Latrotoxin: A Potent Inducer of Secretion
α-Latrotoxin is a 130 kD protein toxin that is found in the black widow spider venom and is the only …
Continue readingAlomone Labs: Twenty Years of Ion Channel Activity
Alomone Labs was established in 1989, and has since grown to be a leading company specialized in the field of …
Continue readingAquaporins: the Waterways of Nature
The importance of the Aquaporin water channels was underscored by awarding the 2003 Nobel Prize in Chemistry to Peter Agre …
Continue readingVoltage-Gated Na+ Channels in the CNS
Voltage-gated Na+ channels are membrane proteins that are essential for the generation and propagation of action potentials in excitable tissues, …
Continue readingTickling the Heart and the Nervous System with the Funny Current
Since their discovery in sinoatrial node cells and neurons in the late 1970s and early 1980s, Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) …
Continue readingCl– Channels Come into Focus
Cl– channels are involved in several physiological functions ranging from epithelial fluid regulation to skeletal muscle contractibility. They are also …
Continue readingCRACking STIM and Orai Currents
Changes in the intracellular free Ca2+ concentration [Ca2+] in regulate a large number of physiological processes and have a major …
Continue readingENaC and ASIC Channels at a Glance
The ENaC/degenerin channel superfamily comprises channels that are not voltage-gated but do involve the passage of ions, namely Na+. These …
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