In 1988, a 21-amino acid endothelium-derived bioactive peptide was cloned and named endothelin (ET)1. Later, two other isoforms differing from …
Continue readingReceptors
Muscarinic Receptors
Acetylcholine, the major neurotransmitter in the central and the peripheral nervous system, can act through two kinds of receptors1: ionotropic …
By Yona Bismuth, M.Sc.
Continue reading The Ionotropic GABAA Receptor
GABA (g-aminobutiric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.1
The GABA transmitter interacts with two major types of receptors: ionotropic GABAA (GABAAR) and the metabotropic GABAB receptors. The GABAAR belong to the ligand-gated ion channel superfamily.2
By Ofra Gohar, Ph.D.
Continue reading The Purinergic P2X Receptors
ATP has been identified as an excitatory neurotransmitter and neuromodulator during physiological processes. The released ATP activates a class of receptors named purinergic receptors: the metabotropic P2Y receptors and the ionotropic P2X receptors1,2. The P2X receptors belong to the ligand-gated ion channel family and are responsible for fast excitatory neurotransmission and are involved in diseases of the nervous system.
By Ofra Gohar, Ph.D.
Continue reading GABA(A) Receptor Family
GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the …
By Ofra Gohar, Ph.D.
Continue reading P2Y Receptor Family
P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiologic responses, among …
By Ofra Gohar, Ph.D.
Continue reading Regulatory Aspects of mGluRs
Metabotropic glutamate receptors (mGluRs) are functionally important for inducing long term potentiation (LTP) and long term depression (LTD). They are …
By Roei Levy, M.Sc., Melanie Grably, Ph.D.
Continue reading In Focus: Ionotropic Glutamate Receptors
The excitatory effects of glutamate (the major excitatory neurotransmitter) are mediated by the activation of ionotropic and metabotropic receptors. These …
By Alomone Labs
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