Ion Channels in Epilepsy

• CGS 20625

  A Partial Agonist of GABA(A) Receptors

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  Cat # C-390

  Source Synthetic

  MW 309.36

  Target GABA(A) receptors

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• Chlormethiazole hydrochloride

  A Positive Modulator of GABA(A) and Glycine Receptors

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  Cat # C-360

  Source Synthetic

  MW 198.11

  Target GABA(A), Glycine receptors

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• CyPPA

  A Selective and Potent Activator of K_Ca2.2 and K_Ca2.3 Channels and a Blocker of TRPM7 Channels

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  Cat # C-110

  Source Synthetic

  MW 285.4

  Target K_Ca2.2, K_Ca2.3, TRPM7 channels

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• (-)-Cytisine

  A nAChR Agonist and a Partial Agonist of β2 Subunit

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  Cat # C-130

  Source Synthetic

  MW 190.2

  Target nAChR

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• DMAB-anabaseine dihydrochloride

  Antagonist or Partial Agonist of nAChR

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  Cat # D-110

  Source Synthetic

  MW 364.3

  Target nAChR

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• Ganaxolone

  A Selective Positive Modulator of GABA(A) Receptors

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  Cat # G-120

  Source Synthetic

  MW 332.5

  Target GABA(A) receptors

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• GV-58

  An Activator of Ca_V2.2 and Ca_V2.1 Ca²⁺ Channels

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  Cat # G-140

  Source Synthetic

  MW 374.2

  Target Ca_V2.1, Ca_V2.2 Ca²⁺ channels

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• Hm1a Toxin

  A Selective and Potent Activator of Na_V1.1 Channels and Blocker of K_V2 and K_V4 Channels

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  Cat # STH-601

  MW 3996.4 Da

  Target Na_V1.1, K_V2, K_V4 channels

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• ICA-27243

  A Potent and Selective Opener of KCNQ2 and KCNQ3 K⁺ Channels

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  Cat # I-130

  Source Synthetic

  MW 268.64

  Target KCNQ2, KCNQ3 K⁺ channels

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• ICA-110381

  An Opener of KCNQ Channels

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  Cat # I-160

  Source Synthetic

  MW 267.1

  Target KCNQ channels

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• Isoguvacine hydrochloride

  An Agonist of GABA(A) Receptors

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  Cat # I-185

  Source Synthetic

  MW 163.6

  Target GABA(A) receptors

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• Isopimaric Acid

  A Novel Opener of K_Ca1.1 Channels

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  Cat # I-370

  Source Natural

  MW 302

  Target K_Ca1.1 K⁺ channels

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• Jingzhaotoxin-II

  An Activator of Na_V Channels

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  Cat # STJ-150

  MW 3561 Da

  Target Na_V Na⁺ Channels

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• MmTx1 Toxin

  A Super Potent Allosteric Modulator of GABA(A) Receptors

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  Cat # STM-550

  MW 7205 Da

  Target GABA(A) receptors

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• MmTx2 Toxin

  A Super Potent Allosteric Modulator of GABA(A) Receptors

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  Cat # STM-600

  MW 7187 Da

  Target GABA(A) receptors

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• Na_V1.1-Compound 3a

  A Modulator of Na_V1.1 Channel

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  Cat # CMN-002

  Source Synthetic

  MW 344.41

  Target Na_V1.1 channels

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• (-)-Nicotine ditartrate

  An Agonist of nAChR

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  Cat # N-175

  Source Synthetic

  MW 462.4

  Target nAChR

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• NMDA

  An NMDA Receptor Agonist

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  Cat # N-170

  Source Synthetic

  MW 147.1

  Target NMDA receptors

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• NS-309

  A Positive Modulator of Small- and Intermediate-Conductance K_Ca Channels

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  Cat # N-180

  Source Synthetic

  MW 231.04

  Target K_Ca2 and K_Ca3.1 K⁺ channels

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• NS-1619

  Selective and Potent Enhancer of K_Ca1.1 Channels and an Inhibitor of SERCA Pumps

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  Cat # N-105

  Source Synthetic

  MW 362.2

  Target K_Ca1.1 K⁺ channels, SERCA pumps

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