Adenosine is a small ubiquitous molecule known for its role as an energy and genetic code building block. Adenosine also serves as a ligand for Adenosine receptors, members of the G-protein coupled receptor superfamily and is involved in many physiological processes including regulation of sleep and the level of arousal, neuroprotection, regulation of seizure susceptibility, locomotor effects as well as involved in many pathophysiological conditions.