Ion Channels in Epilepsy

• OsK-1 Toxin

  A Potent Blocker of K_V1.3 and K_Ca3.1 K⁺ Channels

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  Cat # STO-150

  MW 4205 Da

  Target K_V1.1, K_V1.2, K_V1.3, and K_Ca3.1 K⁺ channels

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• Pandinotoxin Kα

  A Blocker of A-Type and Shaker-Related Voltage-Gated K⁺ Channels

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  Cat # STP-500

  MW 4033 Da

  Target A-type and Shaker-related K⁺ channels

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• Paxilline

  A Mycotoxin Blocker of K_Ca1.1 (BK) Channels and SERCA Pumps

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  Cat # P-450

  Source Natural

  MW 435.6

  Target K_Ca K⁺ channels, SERCA pump

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• PEAQX tetrasodium hydrate

  An Antagonist of NMDA Receptors

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  Cat # P-255

  Source Synthetic

  MW 560.15

  Target NR1, NR2 receptors

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• Penitrem A

  A Blocker of K_Ca1.1 (BK) Channels

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  Cat # P-650

  Source Natural

  MW 634.2

  Target K_Ca1.1 K⁺ channels

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• PF-04856264

  A Specific Blocker of Na_V1.7 Channel

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  Cat # P-265

  Source Synthetic

  MW 437.5

  Target Na_V1.7 channels

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• PF-05089771

  A Potent and Selective Blocker of Na_V1.7 Channel

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  Cat # P-315

  Source Synthetic

  MW 500.34

  Target Na_V1.7 channels

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• PF-05186462

  A Potent and Selective Blocker of Na_V1.7 Channels

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  Cat # P-365

  Source Synthetic

  MW 531.89

  Target Na_V1.7 channels

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• PF-05241328

  A Potent and Selective Blocker of Na_V1.7 Channels

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  Cat # P-345

  Source Synthetic

  MW 436.91

  Target Na_V1.7 channels

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• Phlo1a

  A Blocker of Na_V1.7 Channels

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  Cat # STP-350

  MW 4107 Da

  Target Na_V1.7 channels

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• Phlo1b

  A Blocker of Na_V1.7 Channels

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  Cat # STP-370

  MW 4140 Da

  Target Na_V1.7 channels

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• Phrixotoxin-1

  A Potent Blocker of K_V4.2 and K_V4.3 Channels

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  Cat # STP-700

  MW 3549 Da

  Target K_V4.2, K_V4.3 channels

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• Phrixotoxin-2

  A Potent Blocker of K_V4 Channels

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  Cat # STP-710

  MW 3922 Da

  Target K_V4 channels

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• Phrixotoxin-3

  A Potent Blocker of Na_V1.2 and Na_V1.6 Channels

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  Cat # STP-720

  MW 4060 Da

  Target Na_V1.2, Na_V1.6 channels

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• Picrotoxin

  An Antagonist of GABA(A), Glycine, and 5-HT3 Receptors

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  Cat # P-325

  Source Natural

  MW 602.58

  Target GABA(A), Glycine, 5-HT₃ receptors

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• Pilsicainide hydrochloride

  A Use-Dependent Anti-Arrhythmic Na_V Channel Blocker

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  Cat # P-145

  Source Synthetic

  MW 308.85

  Target TTX-Sensitive Na_V channels

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• ProTx-I

  A Blocker of Na_V, Ca_V3.1, K_V2.1 and TRPA1 Channels

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  Cat # STP-400

  MW 3988 Da

  Target Na_V, Ca_V3.1, K_V2.1, TRPA1 channels

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• ProTx-II

  A Blocker of Na_V1.7 and Na_V1.5 Channels and Some T-Type Ca²⁺ Channels

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  Cat # STP-100

  MW 3826.6 Da

  Target Na_V channels and T-type Ca²⁺ channels

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• ProTx-II-Biotin

  A Blocker of Na_V1.7 and Na_V1.5 Channels and some T-Type Ca²⁺ Channels Conjugated to Biotin

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  Cat # STP-100-B

  MW 4053 Da

  Target Na_V Na⁺ channels and T-type Ca²⁺ channels

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• ProTx-III

  A Potent Blocker of Na_V1.7 Channels

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  Cat # STP-150

  MW 3802 Da

  Target Na_V1.7 channels

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