Ion Channels in Pain

• Ceratotoxin-2

  A Potent Blocker of Central Nervous System Voltage-Gated Na⁺ Channels

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  Cat # STC-100

  MW 4093 Da

  Target Na_V channels

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• Chelerythrine chloride

  An Inhibitor of Protein Kinase C, SERCA Pump, and P2X7 Receptor

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  Cat # C-400

  Source Natural

  MW 383.84

  Target PKC, SERCA pumps, P2X7 receptor

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• Chembridge-5861528

  A Selective Blocker of TRPA1 Channel

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  Cat # C-235

  Source Synthetic

  MW 369.4

  Target TRPA1 channels

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• Cilnidipine

  A Blocker of L- and N-Type Ca_V Channels 

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  Cat # C-135

  Source Synthetic

  MW 492.5

  Target L- and N-type Ca²⁺ channels

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• CNQX

  AMPA/Kainate Receptor Antagonist

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  Cat # C-140

  Source Synthetic

  MW 232.2

  Target AMPA/Kainate receptors

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• CNQX disodium salt

  AMPA/Kainate Receptor Antagonist

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  Cat # C-141

  Source Synthetic

  MW 276.1

  Target AMPA/Kainate receptors

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• CNS-1102

  A Potent NMDA Receptor Antagonist

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  Cat # C-305

  Source Synthetic

  MW 339.86

  Target NMDA receptors

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• Co 102862

  A Potent, State-Dependent Blocker of Neuronal Na_V Channels

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  Cat # C-160

  Source Synthetic

  MW 273.3

  Target Na_V Na⁺ channels

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• Conantokin G

  A Selective and Competitive Antagonist of GluN2B Receptor

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  Cat # STC-666

  MW 2264.2 Da

  Target GluN2B receptor

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• Conantokin R

  An Antagonist of GluN2A and GluN2B Receptors

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  Cat # STC-777

  Source Synthetic peptide

  MW 3098 Da

  Target GluN2B receptor

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• (±)-CPP

  An NMDA Receptor Antagonist

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  Cat # C-175

  Source Synthetic

  MW 252.2

  Target NMDA receptors

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• α-Dendrotoxin

  A Blocker of K_V1.1, K_V1.2, K_V1.6 and ASIC Channels

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  Cat # D-350

  MW 7048 Da

  Target K_V1.1, K_V1.2, K_V1.6, ASIC channels

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• β-Dendrotoxin

  A Potent Blocker of K_V1.1 and K_V1.2 Channels

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  Cat # D-360

  MW ~7000 Da

  Target K_V1.1, K_V1.2 K⁺ channels

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• γ-Dendrotoxin

  A Potent Blocker of K_V1.1 and K_V1.2 Channels

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  Cat # D-370

  MW ~7000 Da

  Target K_V1.1, K_V1.2 K⁺ channels

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• δ-Dendrotoxin

  A Potent and Specific Blocker of K_V1.1 Channels and a Less Potent Blocker of K_ir1.1 (ROMK1) Channels

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  Cat # D-380

  MW 6568 Da

  Target K_V1.1, K_V1.6 and K_ir1.1 K⁺ channels

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• Dendrotoxin-I

  A Potent Blocker of K_V1.1 and K_V1.2 Channels

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  Cat # D-390

  MW 7149 Da

  Target K_V1.1, K_V1.2 K⁺ channels

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• Dendrotoxin-K

  A Potent Blocker of K_V1.1 and K_V1.2 Channels

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  Cat # D-400

  MW 6560 Da

  Target K_V1.1, Kv1.1-containing heterooligomer.

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• D-AP5

  A Competitive NMDA Receptor Antagonist

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  Cat # D-145

  Source Synthetic

  MW 197.1

  Target NMDA receptors

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• DL-AP5

  A Competitive NMDA Receptor Antagonist

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  Cat # D-140

  Source Synthetic

  MW 197.1

  Target NMDA receptors

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• 5-(N,N-Dimethyl)amiloride hydrochloride

  A Blocker of TRPA1 Channels and Selective Blocker of Na⁺/H⁺ and Na⁺/Ca²⁺ Exchangers

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  Cat # D-165

  Source Synthetic

  MW 294.1

  Target TRPA1 channel, Na⁺/H⁺ and Na⁺/Ca²⁺ exchangers

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