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Endothelin Receptors

Endothelin, a 21–amino acid peptide, has potent and sustained vasoconstrictive effects on vascular smooth muscle both in vivo and in vitro and is found in three different isoforms. ET-1 binds and activates two G-protein coupled receptors: ET-A and ET-B. While the former has been attributed to vasoconstriction, the role of ET-B depends mostly on its location; on one hand it could promote vasoconstriction and on the other stimulate nitric oxide (NO) release -a known vasodilator.

  • Anti-Endothelin Receptor A (extracellular) Antibody

    Cat # AER-004
    Type Polyclonal
    Host Rabbit
    Applications ifc, lci, wb
    Reactivity h, m, r
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