ENaC channels are composed of three structurally related subunits: α, β, and γ which mostly coassemble as heteromeric structures in order to form functional channels. Structurally, channels belonging to the ENac/ Degenerin superfamily have short N- and C-termini and a large extracellular loop. In addition, strong evidence suggests that furin proteases cleave their extracellular loop for full channel activation. These channels are highly sensitive to amiloride and are hence commonly termed amiloride-sensitive channels.