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Multiplex Staining Products

Alomone Labs has developed two innovative platforms for studying protein-protein interaction and/or protein co-localization in complex immunostaining or immunoprecipitation protocols:

 

ATTO-Conjugated Antibodies: These antibodies can be used in immunohistochemistry (IHC) and immunocytochemistry (ICC) with same species antibodies.

 

Save time and resources with ONE antibody.

 

Benefits of immunostaining with ATTO-conjugated antibodies:
Direct immuno-fluorescence
Secondary antibodies are not necessary
Ideal for immuno-colocalization with same species/host antibodies

 

More on ATTO dyes

 

Guinea Pig-Raised Antibodies: Antibodies raised in guinea pig can be used with any non-guinea pig second species antibodies (e.g. antibodies raised in mouse, rabbit, goat, etc.) in complex immunostaining or immunoprecipitation protocols. Our line of guinea pig raised antibodies can be combined with any of our rabbit-raised or ATTO-conjugated antibodies in complex immunostaining protocols.

Glial-Derived Neurotrophic Factor (GDNF) Family

The GDNF family ligands (GFLs) belong to the super family of the TGF-β. They belong to the group of cystine-knot protein and function as homodimers. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN). These factors are heavily involved in the development and function of the nervous system (both central and peripheral). In general GFLs all signal through a signal through the receptor tyrosine kinase Ret. Their specificity is implemented by different GDNF family receptor α (GFRα), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRα1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret.

  • human GDNF-Biotin

    Biotinylated human Glial Cell Line-Derived Neurotrophic Factor

    Cat # G-240-B
    Source Modified recombinant protein, E. coli
    MW 30.8 kDa (dimer)
    Target GFRA1 (GDNFR-Alpha-1), RET Receptor Tyrosine Kinase
    • Bioassay Tested
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