Flow Cytometry has never been simpler

Alomone Labs FITC-conjugated extracellular antibodies offer you significant advantages. Skip cell permeabilization/fixation.

NOW you can conduct flow cytometry using live cells in ONE single step.

These novel antibodies save you valuable time and resources, while empowering your research results.

Benefits:

✓ Developed for flow cytometry (FACS)
✓ Tested with appropriate isotype control
✓ No need for secondary antibodies
✓ Conjugated to “extracellular” antibodies
✓ Cell-surface detection of proteins
✓ Permeabilization & cell fixation not required
✓ Time saving

Within our antibody portfolio, we gladly take on special requests for customized antibody labeling/conjugation.

Connect with us. We are here for you.

Protease-activated receptors (PARs) belong to the superfamily of G-protein coupled receptors. (PAR-1 – 4) are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this novel modality of activation, a specific protease cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This results in the creation of a new N-terminal tethered ligand, which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways.