Four members of the TRPV family have been described as a thermosensitive ion channels (TRPV1 to TRPV4). Each channel exhibits distinct thermal activation thresholds ranging from noxious cold (<17°C) to noxious heat (>52°C).TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX) and lipids. This channel is associated with tissue injury and inflammation.