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K⁺ selective channels are some of the most widespread ion trafficking molecules in living organisms, with more than 70 genes encoding different K⁺ channels in humans. K_V channels fall into one of the two classical categories of delayed rectifier (DR) and A-type. Delayed rectifier was the original name attributed to voltage-dependent K⁺ channels due to their delayed activation in squid giant axons. A-type channels are low voltage-activated, fast inactivating (therefore, transient) K⁺ channels. Specific K_V toxins are often used to dissect the particular contribution of different subunits to native currents.