Voltage-dependent Ca²⁺ channels (Ca_V) form an important route for Ca²⁺ entry into cells, upon deviations from the cells’ resting membrane potential. There are ten Ca_V α1 subunit genes, divided into three subfamilies on both a functional and sequence homology basis. The Ca_V1 subfamily includes four genes which encode the L-type channels, the Ca_V3 subfamily includes three genes encoding the T-type channels and the Ca_V2 subfamily consists of three isoforms encoding P/Q- , N- and R-type channels, with all three contributing to neurotransmitter release in neurons.

Alomone Labs is excited to offer a line of Overexpressed Membrane Fractions. These membrane fractions are Xenopus oocyte membrane lysates overexpressing a specific ion channel. Fractions are sold as a set of injected and non-injected oocytes and can be used as controls for Alomone Labs antibodies. 

Overexpressed Membrane Fractions can also be purchased as a kit with their respective antibody. Membrane fractions enable end users to verify/validate the specificity of Alomone Labs antibodies.