Studying membrane proteins, namely ion channels, is often challenging due to the nature of their complex structure. That’s why we have developed a novel tool for detecting ion channels in living cells and tissues, emphasizing the unique and distinct properties of peptide toxins. Highly potent and reliable, these labeled toxins offer clear visual detection while remaining active.
Why use ATTO/Biotin-labeled toxins?
✓ Localization and distribution
✓ Clustering and internalization kinetics
✓ Live cell imaging
✓ Single cell detection
✓ Binding kinetics
Learn more about ATTO dyes | View the labeled toxins portfolio
Probes for GABA(A) Receptors & Nicotinic Acetylcholine Receptors
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Alomone Labs α-Bungarotoxin-FITC in whole mount staining of mice Gastrocnemius muscle.α-Bungarotoxin-FITC (#B-100-F)The image was taken using Nikon Epifluorescence microscopy at 60X magnification and is kindly provided by Dr. Eran Perlsson, Dept. of Physiology and Pharmacology, Tel-Aviv University, Tel-Aviv, Israel. |
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Alomone Labs α-Bungarotoxin-ATTO Fluor-488 in whole mount staining of mice Gastrocnemius muscle.α-Bungarotoxin-ATTO Fluor-488 (#B-100-AG) |
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Bungarotoxin binding sites co-localize with GABAergic neurons expressing parvalbumin in mouse hippocampal CA1 region.α-Bungarotoxin-Biotin (#B-100-B) |
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Alomone Labs α-Bungarotoxin-ATTO Fluor-633 in whole mount staining of mice neuromuscular junction (NMJ).α-Bungarotoxin-ATTO Fluor-633 (#B-100-FR)The image was taken using Nikon Epifluorescence microscopy at 60X magnification and is kindly provided by Dr. Eran Perlsson, Dept. of Physiology and Pharmacology, Tel-Aviv University, Tel-Aviv, Israel. |
Probes for Kir Channels
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Double staining of GIRK2 channels in substantia nigra pars compacta using Tertiapin-Q-ATTO Fluor-488 and Guinea pig Anti-Kir3.2 (GIRK2) Antibody.Tertiapin-Q-ATTO Fluor-488 (#STT-170-AG) |
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Alomone Labs Tertiapin-Q-ATTO Fluor-633 binds GIRK1/GIRK4-GFP transfected HEK293T cells.Tertiapin-Q-ATTO Fluor-633 (#STT-170-FR)The pictures are a kind gift from the lab of Prof. Eithan Reuveny, Weizmann Institute, Israel. |
Probes for KV Channels
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Tityustoxin-Kα-ATTO Fluor-594 labels KV1.2 channel in mouse cerebellum.Tityustoxin-Kα-ATTO Fluor-594 (#STT-360-AR) |
Within our portfolio, we gladly take on special requests for customized protein/peptide labeling.