Changes in the intracellular free Ca2+ concentration [Ca2+] in regulate a large number of physiological processes and have a major …
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Issue No. 25
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ENaC and ASIC Channels at a Glance
The ENaC/degenerin channel superfamily comprises channels that are not voltage-gated but do involve the passage of ions, namely Na+. These …
Continue readingTetrodotoxin – A Powerful Molecular Tool in Excitable Tissues
Tetrodotoxin (TTX) is an organic molecule that is very toxic to mammals and many other organisms. It is produced by …
Continue readingIn Focus: Two Pore Segment Channels (TPCs)
Among various vertebrate species, three genes are known to encode two pore segment channels (TPCs) termed TPC1-3. Interestingly, TPC3 seems …
Continue readingIn Focus: Connexin and Pannexin Gap Junction Channels
Gap junctions are usually found in clusters and enable intercellular communication by allowing the passage of small molecules between cells2. …
Continue readingIn Focus: Ionotropic Glutamate Receptors
The excitatory effects of glutamate (the major excitatory neurotransmitter) are mediated by the activation of ionotropic and metabotropic receptors. These …
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