Neurotrophins, like many growth factors, are expressed as precursor proteins which are then truncated and further modified to yield the …
Continue readingNeurotrophin Pathways
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NGF: One Molecule, Multiple Functions
Nerve Growth Factor (NGF) is one of the founding and best-characterized members of the neurotrophin family. This family comprises a …
By Dovrat Brass, Ph.D., B.Pharm
Continue reading BDNF – Second Best?
Brain Derived Neurotrophic Factor (BDNF) is the second best characterized neurotrophin (following NGF) and acts as a key contributor to …
By Alon Meir, Ph.D.
Continue reading p75NTR – The Promiscuous Receptor
The p75 neurotrophin receptor (p75NTR) could bind a variety of proteins all with biological significance. While this receptor has no …
By Melanie Grably, Ph.D.
Continue reading GDNF – a Neurotrophic Survival Factor
Glial-Derived Neurotrophic Factor (GDNF) is the major member of the GDNF family protein which is distantly related to the TGF-β …
By Yossi Anis, Ph.D.
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