Overview
Alternative Name α-CTx ImI
Scientific background α-Conotoxin ImI is a 12 amino acid peptidyl toxin isolated from Conus Imperialis venom1, which blocks mammalian neuronal nAChRs located on postsynaptic membranes. This toxin inhibits mammalian neuronal nAChRs (α3/β2 > α7 > α3/β4) in a voltage-independent manner and has no effect on nAChRs composed of α2/β2, α3/β2, α4/β2, α2/β4, α3/β4, or α4/β4 subunits1,2.
For research purposes only, not for human use
Specifications
Applications
Our Bioassay
Our bioassay
Alomone Labs α-Conotoxin ImI inhibits α3/β2 nAChRs expressed in Xenopus oocytes.A. Representative time course of α3/β2 current inhibition by 100 nM (green) and 1 µM (magenta) α-Conotoxin ImI (#C-290). Currents were elicited every 50 sec by transient applications of 2 µM ACh, while membrane potential was held at -60 mV, and inhibited by 100nM and 1 µM α-Conotoxin ImI.
B. Superimposed traces of α3/β2 currents evoked by ACh (arrow) after application of control (black), 100nM (green) and 1 µM (magenta) α-Conotoxin ImI (Taken from the recording in A).
Last Update: 08/01/2025
