Overview
Neuronal bungarotoxin, nBgt, Toxin F
- Chiappinelli, V. A. et al. (1996) Toxicon, 34, 1243.
Alomone Labs κ-Bungarotoxin inhibits α3/β2 nAChRs expressed in Xenopus oocytes.A. Representative time course of α3/β2 current inhibition by 25 nM κ-Bungarotoxin (#B-300). Currents were elicited every 50 sec by transient applications of 20 µM ACh, while membrane potential was held at -80 mV, and inhibited by 25 nM (green) κ-Bungarotoxin.
B. Superimposed traces of α3/β2 currents evoked by ACh (arrow) after application of control (black) and 25 nM (green) κ-Bungarotoxin (taken from the recording in A).
- Chiappinelli, V. A. (1983) Brain Res., 277, 9.
- Grant, G. A. and Chiappinelli, V.A. (1985) Biochemistry, 24, 1532.
- Chiappinelli, V. A. et al. (1996) Toxicon, 34, 1243.
- Chiappinelli, V. A. and Lee, J.C. (1985) J. Biol. Chem., 260, 6182.
- Grant, G.A. et al. (1997) Biochemistry, 36, 3353.
- Osipov, A.V. et al. (2008) J. Biol. Chem., 283, 14571.
- Ho, T.N.T. et al. (2020) Front. Neurosci., 14, 609005.
Kappa-bungarotoxin (κ-Bungarotoxin, κ-Bgt) is a 66 amino acid peptidyl toxin isolated from the venom of the banded krait snake, Bungarus multicinctus1,2. κ-Bgt is a postsynaptic neurotoxin that potently binds and inhibits the neuronal types of nicotinic acetylcholine receptors (nAChR). It is a selective antagonist of α3-containing and some α4-containing nAChRs subunits3.
Under physiological solvent conditions, κ-Bungarotoxin exists as a non-covalent homodimer4. The dimeric nature of the toxin may play a crucial role in the binding properties of κ-Bgt to neuronal types of AChRs while losing its potency on muscle receptors4-6.
Neuronal nicotinic acetylcholine receptors (nAChRs) are prototypical cation-selective, ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems. nAChRs are involved in a range of physiological and pathological functions and hence are important therapeutic targets7. The κ-neurotoxins have been valuable pharmacological tools in the study of neuronal AChRs3.
κ-Bungarotoxin (#B-300) is a highly pure, natural, and biologically active peptide toxin.
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