Overview
κ-Conotoxin RIIIJ (#STC-660) is a highly pure, synthetic, and biologically active peptide toxin.
Alternative Name κ-M-RIIIJ
Structure
For research purposes only, not for human use
Applications
Citations (1)
Citations
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- Smith, K.E. et al. (2015) J. Neurosci. 35, 11221.
Specifications
Properties
Technical Specifications
Origin Synthetic peptide
MW 2807.9 Da
Sequence LXXCCTXXKKHCXAXACKYKXCCKS.
Modifications Disulfide bonds between Cys4-Cys17, Cys5-Cys22 and Cys12-Cys23. X = Hydroxyproline.
Peptide Content 100%
Purity >98% (HPLC)
Molecular formula C117H184N32O36S6.
Accession number P0CG45.
Biological Activity
Target KV1.2 K+ channels
Effective concentration 30 nM.
Activity κ-Conotoxin RIIIJ is a blocker of KV1.2 channels1.
References
- Chen, P. et al. (2010) J. Biol. Chem. 285, 14882.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or three months at -20°C.
Scientific Background
Scientific Background
Scientific background
κ-conotoxin RIIIJ (κ-M-RIIIJ), is a peptide toxin belonging to the conotoxin M superfamily, and was originally isolated from Conus radiatus (Rayed cone) venom. This conopeptide inhibits the homotetrameric human KV1.2 channels (IC50 = 33 nM)3. κ-M-RIIIJ was found to exert cardioprotective effects, presumably due to the high affinity of this peptide for mammalian KV1.2 and KV1.2- containing heteromultimers3.
Voltage-gated K+ channels represent a structurally and functionally diverse group of membrane proteins. These channels establish the resting membrane potential and modulate the frequency and duration of action potentials in nerve and muscle1,2.
References
- Hille, B. (1992) Ionic Channels of Excitable Membranes, 2nd Ed. Sunderland, MA: Sinauer Associates.
- Gulbis J. M. et al. (2002) Novartis Found. Symp. 245, 127
- Chen, P. et al. (2010) J. Biol. Chem. 285, 14882.
Last Update: 08/01/2025
