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Overview
(±)-Bay K8644 (#B-350) is a highly pure, synthetic, and biologically active compound.
Structure
For research purposes only, not for human use
Applications
Citations (30)
Citations
Powered by BiozProduct citations
- Dahan, T. et al. (2017) Diabetes 66, 426.
- Teraoku, H. and Lenzen, S. (2017) J. Diabetes Res. 2017, 2309630.
- Gurgul-Convey, E. (2015) Biochem. Biophys. Res. Commun. 464, 13.
- He, S. et al. (2014) J. Neurosci. 34, 5261.
- Dominguez, B. et al. (2009) Am. J. Physiol. 296, E1148.
- Kaisman-Elbaz, T. et al. (2009) J. Cell. Physiol. 220, 222.
- Husch, A. et al. (2008) J. Neurophysiol. 99, 320.
- Hutchins, B.I. and Kalil, K. (2008) J. Neurosci. 28, 143.
- Perissinotti, P.P. et al. (2008) Eur. J. Neurosci. 27, 1333.
- Worrell, J.W. and Levine, R.B. (2008) J. Neurophysiol. 100, 868.
Specifications
Properties
Technical Specifications
MW 356.3
Purity >99% (HPLC)
Molecular formula C16H15F3N2O4.
CAS No. 71145-03-4
Source Synthetic
Chemical name 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl) phenyl]-3-pyridinecarboxylic acid, methyl ester.
Biological Activity
Target L-type Ca2+ channels
Effective concentration 1-5 μM.
Activity (±)-Bay K8644 is a dihydropyridine that acts as an L-type, voltage-gated Ca2+ channel agonist. The (-)-enantiomer has strong Ca2+ channel agonist properties, whereas the (+)-enantiomer has weak Ca2+ channel antagonist activity. The net activity of the racemic mix is L-type channel opening. In the presence of this agonist, channels tend to open for longer periods causing a large increase in the channel microscopic response1-4. (±)-Bay K8644 is also an inhibitor (by increasing the inactivation) of a Shaker KV channel5.
References
- Hess, P. et al. (1984) Nature 311, 538.
- Nowycky, M.C. et al. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 2178.
- Bechem, M. and Hoffmann, H. (1993) Pflugers Arch. 424, 343.
- Triggle, D.J. and Rampe, D. (1989) Trends Pharmacol. Sci. 10, 507.
- Avdonin, V. et al. (1997) J. Gen. Physiol. 109, 169.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Ethanol, methanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Scientific Background
References
Scientific background
(±)-Bay K8644 is an opener of all L-type channels (CaV1 family). In the presence of this agonist, channels tend to open for longer periods causing a large increase in the channel macroscopic response.
The net activity of the racemic mix is that of the (-)-enantiomer agonistic activity.
(±)-Bay K8644 is a widely used L-type Ca2+ channel activator in various neuronal, muscle, endocrine, thyroid and other cell types.1-3
References
- Hess, P. et al. (1984) Nature 311, 538.
- Nowycky, M.C. et al. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 2178.
- Bechem, M. and Hoffmann, H. (1993) Pflugers Arch. 424, 343.
Last Update: 08/01/2025
