Overview
µ-Conotoxin KIIIA (#C-280) is a highly pure, synthetic, and biologically active peptide toxin.
Structure
For research purposes only, not for human use
Applications
Citations (13)
Citations
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Properties
Technical Specifications
Origin Synthetic peptide
MW 1883 Da
Sequence CCNCSSKWCRDHSRCC.
Modifications Disulfide bonds between Cys1-Cys9, Cys2-Cys15 and Cys4 -Cys16. Cys16 - C-terminal amidation.
Peptide Content 100%
Purity >99% (HPLC)
Molecular formula C70H100N28O22S6.
Biological Activity
Target TTX-sensitive Na+ channels
Effective concentration 0.1-10 μM.
Activity μ-Conotoxin KIIIA specifically and in some cases reversibly blocks TTX-sensitive mammalian voltage-dependent Na+ (NaV) channels1.
References
- Zhang, M.M. et al. (2007) J. Biol. Chem. 282, 30699.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or three months at -20°C.
Scientific Background
References
Scientific background µ-Conotoxin KIIIA is a toxin originally isolated from the venom of Conus Kinoshitai1. µ-Conotoxin KIIIA specifically, and in some cases reversibly, blocks TTX-sensitive mammalian voltage-dependent Na+ (NaV) channels2. In addition, µ-Conotoxin KIIIA was found to act as an effective analgesic in an inflammatory pain assay in mice in vivo2,3.
References
- Bulaj, G. et al. (2005) Biochemistry 44, 7259.
- Zhang, M.M. et al. (2007) J. Biol. Chem. 282, 30699.
- Norton, R.S. (2010) Molecules 15, 2825.
Last Update: 08/01/2025
