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Overview
α-Pompilidotoxin (#P-170) is a highly pure, synthetic, and biologically active peptide toxin.
Alternative Name α-PMTX
Structure
For research purposes only, not for human use
Applications
Citations (1)
Citations
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Properties
Technical Specifications
Origin Synthetic peptide
MW 1529 Da
Sequence RIKIGLFDQLSKL.
Modifications Lys13 - C-terminal amidation.
Peptide Content 100%
Purity >98% (HPLC)
Molecular formula C71H123N19O18.
Biological Activity
Target TTX-sensitive Na+ channels
Effective concentration 10-100 µM.
Activity α-Pompilidotoxin slows NaV channel inactivation without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3.
References
- Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961.
- Konno, K. et al. (2000) Neurosci. Lett. 285, 29.
- Konno, K. et al. (1998) Biochem. Biophys. Res. Commun. 250, 612.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
Scientific Background
References
Scientific background
α-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide. α-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitate both excitatory and inhibitory synaptic transmission.
Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 Effective at concentrations of 10 nM in cultured rat cortical neurons.4
References
- Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961.
- Konno, K. et al. (2000) Neurosci. Lett. 285, 29.
- Konno, K. et al. (1998) Biochem Biophys. Res. Commun. 250, 612.
- Harsch, A. et al. (1998) Neurosci. Lett. 252, 49.
Last Update: 08/01/2025
