Overview
Alternative Name α-PMTX
Lyophilized Powder yes
Origin Synthetic peptide
MW: 1529 Da
Purity: >98% (HPLC)
Effective concentration 10-100 µM.
Sequence RIKIGLFDQLSKL.
Modifications Lys13 - C-terminal amidation.
Structure
Molecular formula C71H123N19O18.
Activity α-Pompilidotoxin slows NaV channel inactivation without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse1-3.
References-Activity
- Sahara, Y. et al. (2000) Eur. J. Neurosci. 12, 1961.
- Konno, K. et al. (2000) Neurosci. Lett. 285, 29.
- Konno, K. et al. (1998) Biochem. Biophys. Res. Commun. 250, 612.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
Our bioassay
Alomone Labs α-Pompilidotoxin enhances native NaV currents in ND7-23 cells.The effect on inward currents of a bath application of 100 µM α-Pompilidotoxin (#P-170) (cyan). NaV currents were elicited every 15 sec from a holding potential of -100 mV, by 20 ms test pulses to -10 mV.
Scientific background
α-PMTX was originally isolated from Anoplius samariensis and Batozonellus maclifrons wasps. This is a synthetic version of the peptide. α-PMTX induces a unique pattern of repetitive action potentials previous seen with other neurotoxins and thus facilitate both excitatory and inhibitory synaptic transmission.
Recently it was found that this toxin slows the Na+-channel inactivation, without changing the peak current-voltage relationship or the activation time course of the TTX-sensitive Na+ currents in the neuromuscular synapse of the lobster walking leg and in the rat trigeminal ganglion neurons.1-3 Effective at concentrations of 10 nM in cultured rat cortical neurons.4
Target TTX-sensitive Na+ channels
Peptide Content: 100%
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
Citations
