Overview
Alternative Name αC-PrXA
Lyophilized Powder yes
Origin Synthetic peptide
MW: 3541 Da
Purity: >98% (HPLC)
Effective concentration 1-20 nM.
Sequence TYGIYDAKPXFSCAGLRGGCVLPXNLRXKFKE.
Modifications Disulfide bond between Cys13-Cys20. X = Hydroxyproline. Glu32 - C-terminal amidation.
Structure
Chemical name
Molecular formula C160H247N43O44S2
Activity αC-Conotoxin PrXA reversibly blocks both adult and fetal mammalian muscle α1/β1/ε/δ and α1/β1/γ/δ nicotinic ACh receptor1.
References-Activity
- Jimenez, E.C. et al. (2007) Biochemistry 46, 8717.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs αC-Conotoxin PrXA inhibits muscle α1/β1/γ/δ nAChR heterologously expressed in Xenopus oocytes.A. Time course of αC-Conotoxin PrXA (#STC-620) action on muscle α1/β1/γ/δ nAChR. Current amplitudes were plotted as a function of time. Membrane potential was held at –80 mV and oocytes were stimulated by exposure to 100 μM acetylcholine every 100 seconds. 20 nM (for 6 min) αC-Conotoxin PrXA were perfused during the period marked by the bar, as indicated. B. Superimposed traces of muscle nAChR channel current in the absence (black) and presence (green) of 20 nM αC-Conotoxin PrxA (taken from the experiment in A).
Scientific background αC-Conotoxin PrXA is a synthetic peptide purified to homogeneity, originally isolated from the Conus parius venom1. αC-Conotoxin PrXA reversibly blocks both adult and fetal mammalian muscle α1/β1/ε/δ and α1/β1/γ/δ nicotinic ACh receptors1.
Target α1/β1/γ/δ nAChR
Peptide Content: 100%
Lyophilized Powder
For research purposes only, not for human use
Last Update: 07/05/2024
Specifications
Citations
Citations
