Overview
Scientific background ω-Conotoxin CVIB is a peptide toxin originally isolated from the cat cone (Conus Catus). It is a blocker of voltage-gated N-,P- and Q-type CaV channels. CVIB has an effective concentration of 1-10 nM with an IC50 of 7.7 nM for N-type channels and 11 nM for P- and Q-type channels. Compared to other ω-conotoxins, CVIB is a fairly poor inhibitor of N-type channels and only a moderate inhibitor of P- and Q-type channels. Cloning and sequencing of mRNA transcripts from the venom ducts of the sea-snail failed to isolate CVIB’s mRNA transcript thus suggesting that this ω-conotoxin is not found abundantly in the Conus Catus species and may be found in other species of the cone snail family1.
For research purposes only, not for human use
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Our Bioassay
Our bioassay
Alomone Labs ω-Conotoxin CVIB blocks CaV2.2 currents heterologously expressed in Xenopus oocytes.A. Time course of ω-Conotoxin CVIB (#STC-410) action on CaV2.2 maximum current amplitude. Current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage ramp to +50 mV in 2 mM Ba2+. 10 nM ω-Conotoxin CVIB were perfused as indicated by the bar (green) for 5 min. B. Superimposed examples of CaV2.2 channel maximum peak current in the absence (control) and presence (green) of 10 nM ω-Conotoxin CVIB (taken from the experiment in A).
Last Update: 08/01/2025
