Overview
ω-Conotoxin MVIID (#STC-751) is a highly pure, synthetic, and biologically active peptide toxin.
Alternative Name SNX-238
Structure
For research purposes only, not for human use
Applications
Citations (2)
Citations
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Properties
Technical Specifications
Origin Synthetic peptide
MW 2695 Da
Sequence CQGRGASCRKTMYNCCSGSCNRGRC.
Modifications Disulfide bonds between Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25. Cys25 - C-terminal amidation.
Peptide Content 100%
Purity >98% (HPLC)
Molecular formula C99H164N42O33S7.
Accession number Q26350.
Biological Activity
Target N-, P-type Ca2+ channels
Effective concentration 200 nM - 1 µM.
Activity ω-Conotoxin MVIID is a voltage-gated N-type Ca2+ channel blocker1.
References
- Monje, V.D. et al. (1993) Neuropharmacology 32, 1141.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or three months at -20°C.
Scientific Background
References
Scientific background ω-conotoxins are small, disulfide-rich peptides from the venoms of predatory cone snails that inhibit neuronal voltage-gated Ca2+ channels involved in neurotransmitter release. ω-conotoxin-MVIID (ω-CTx-MVIID) was identified by sequence homology from Conus magus (Magician's cone snail) cDNA library1,4. ω-CTx-MVIID blocks Ca2+ current activated in whole-cell patch-clamp recordings from central neurons of goldfish2. ω-conotoxin MVIID exhibits greater discrimination against the N-channel subtype than any other ω-conotoxin variant to date. ω-conotoxin MVIID has effects on “P-like” subtypes of Ca2+ channels. Furthermore, ω-CTx-MVIID inhibits synaptosomal voltage-sensitive Ca2+ uptake3.
References
- Haack, J.A. et al. (1993) Neuropharmacology 32, 1151.
- Tabata, T. et al. (1995) Neuropharmacology 35, 633.
- Gandia, L. et al. (1997) Pflugers Arch 435, 55.
- Monje, V.D. et al. (1993) Neuropharmacology 32, 1141.
Last Update: 08/01/2025
