Overview
3-AQC (#A-205) is a highly pure, synthetic, and biologically active compound.
Structure
For research purposes only, not for human use
Applications
Specifications
Properties
Technical Specifications
MW 395.41
Purity >98%
Molecular formula C20H21N5O4.
CAS No. 149685-89-2
Source Synthetic
Chemical name 3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate.
Biological Activity
Target 5-HT3A channel
Effective concentration 1-100 µM.
Activity 3-AQC is a potent and selective 5-HT3A receptor antagonist1.
References
- Monge, A. et al. (1993) J. Med. Chem. 36, 2745.
Solubility and Storage
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Scientific Background
References
Scientific background
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.
3-AQC is a potent and selective antagonist of the 5-HT3A channel. 3-AQC is a derivative of Piperazinyquinoxaline synthetically designed to be 100 times more potent in blocking Serotonin receptors than Tropisetron.
References
- Hannon, J. and Hoyer, D. (2008) Behav. Brain Res. 195, 198.
- Monge, A. et al. (1993) J. Med. Chem. 36, 2745.
Last Update: 08/01/2025
