Name: 5'-Iodoresiniferatoxin
Brand: Alomone Labs
SKU: I-800

Overview

Cat #: I-800

Alternative Name 5'-IRTX

Lyophilized Powder yes

Origin Euphorbia resinifera (Moroccan cactus).

Source Semi-synthetic

MW: 754.6

Purity: >99%

Effective concentration 100 nM - 10 µM.

Structure

Chemical name 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzene acetate).

Molecular formula C₃₇H₃₉IO₉.

CAS No.: 535974-91-5

Activity 5'-Iodoresiniferatoxin is a potent and partial blocker of TRPV1 (Vanilloid/Capsaicin receptor 1) channel¹. It also abolishes the inhibitory effect of capsaicin on Ca_V currents in DRG neurons².

References-Activity

Wahl, P. et al. (2001) Mol. Pharmacol. 59, 9.
Wu, Z.Z. et al. (2005) J. Biol. Chem. 280, 18142.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions Up to two weeks at 4°C or six months at -20°C.
Protect from light.

Our bioassay

Alomone Labs 5'-Iodoresiniferatoxin inhibits Capsaicin induced Ca²⁺ influx via the activation of TRPV1 expressed in HEK-293 cells.
Cells were loaded with 1 mM fluo-3 AM and then stimulated with 10 µM capsaicin in the absence (blue) or presence (purple) of 100 nM and 200 nM (green) 5'-Iodoresiniferatoxin (#I-800). The figure shows intracellular Ca²⁺ levels before and after stimulation of cells with 10 µM capsaicin.

References - Scientific background

Wahl, P. et al. (2001) Mol. Pharmacol. 59, 9.
Wu, Z.Z. et al. (2005) J. Biol. Chem. 280, 18142.

Scientific background 5’-Iodoresiniferatoxin (5’-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.¹ It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5’-Iodoresiniferatoxin partially blocked capsaicin-induced currents in Xenopus oocytes expressing TRPV1 channels (IC₅₀= 3.9 nM).¹ 5’-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on Ca_V currents (probably mediated by TRPV1) in DRG neurons.

Target TRPV1 channels

Lyophilized Powder

5’-Iodoresiniferatoxin (#I-800) is a highly pure, semi-synthetic, and biologically active compound.

Certificate of Analysis SDS

For research purposes only, not for human use

Last Update: 02/01/2024

Applications

Citations

Product citations

Spencer, N.G. et al. (2016) PLoS ONE 11, e0162497.
Kornilov, P. et al. (2014) FASEB J. 28, 2591.
Jin, M.C. et al. (2013) Eur. J. Lipid Sci. Technol. 115, 1284.

Navigation

Order Summary

5′-Iodoresiniferatoxin

Overview

Applications

Citations

Specifications

Scientific Background

Need Help With This Product?