Overview
Alternative Name 5'-IRTX
Lyophilized Powder yes
Origin Euphorbia resinifera (Moroccan cactus).
Source Semi-synthetic
MW: 754.6
Purity: >99%
Effective concentration 100 nM - 10 µM.
Structure
Chemical name 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzene acetate).
Molecular formula C37H39IO9.
CAS No.: 535974-91-5
Activity 5'-Iodoresiniferatoxin is a potent and partial blocker of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1. It also abolishes the inhibitory effect of capsaicin on CaV currents in DRG neurons2.
References-Activity
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
Protect from light.
Protect from light.
Our bioassay
Alomone Labs 5'-Iodoresiniferatoxin inhibits Capsaicin induced Ca2+ influx via the activation of TRPV1 expressed in HEK-293 cells.Cells were loaded with 1 mM fluo-3 AM and then stimulated with 10 µM capsaicin in the absence (blue) or presence (purple) of 100 nM and 200 nM (green) 5'-Iodoresiniferatoxin (#I-800). The figure shows intracellular Ca2+ levels before and after stimulation of cells with 10 µM capsaicin.
Scientific background 5’-Iodoresiniferatoxin (5’-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5’-Iodoresiniferatoxin partially blocked capsaicin-induced currents in Xenopus oocytes expressing TRPV1 channels (IC50 = 3.9 nM).1 5’-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on CaV currents (probably mediated by TRPV1) in DRG neurons.
Target TRPV1 channels
Lyophilized Powder
For research purposes only, not for human use
Last Update: 02/01/2024
Specifications
Citations
Citations
