Overview
Alternative Name 6’-IRTX
Lyophilized Powder yes
Origin Euphorbia resinifera (Moroccan cactus).
Source Semi-synthetic
MW: 754.6
Purity: >98%
Effective concentration 50 nM - 1 μM.
Structure
Chemical name Resiniferonyl 20-(4-hydroxy-2-iodo-5-methoxyphenylacetate 9,13,14-ortho(phenylacetate).
Molecular formula C37H39IO9.
CAS No.: 335151-55-8
Activity 6'-Iodoresiniferatoxin is a partial activator of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1.
References-Activity
- McDonnell, M.E. et al. (2002) Bioorg. Med. Chem. Lett. 12, 1189.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to two weeks at 4°C or six months at -20°C.
Protect from light.
Protect from light.
Our bioassay
Alomone Labs 6'-Iodoresiniferatoxin induces Ca2+ influx via activation of TRPV1 expressed in HEK293 cells.Cells were loaded with 2 mM fluo-3 AM and then stimulated with 6’-Iodoresiniferatoxin (#I-805). The left panel shows the intracellular Ca2+ levels 10 sec post stimulation with different concentrations of 6’-Iodoresiniferatoxin (ED50 = 0.8 μM) and plotted against drug concentration. The right panel shows intracellular Ca2+ levels before and after stimulation of cells with 2.5 μM 6’- Iodoresiniferatoxin.
References - Scientific background
- McDonnell, M.E. et al. (2002) Bioorg. Med. Chem. Lett. 12, 1189.
Scientific background 6’-Iodoresiniferatoxin is an agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). It displayed high affinity binding (Ki=0.71 nM) for the human TRPV1 receptor and functioned as a partial agonist.1
Target TRPV1 channels
Lyophilized Powder
6’-Iodoresiniferatoxin (#I-805) is a highly pure, semi-synthetic, and biologically active compound.
For research purposes only, not for human use
Last Update: 02/01/2024
Applications
Citations
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