Overview
- Webling K. et al. (2016) Neuropeptides 60, 75.
Alomone Labs Ala5-Galanin (2-11) activates Galanin 2 receptor-mediated Ca2+ mobilization in CHO-K1-Gα16-mt Aequorin cells.Dose-response of normalized activation of Galanin 2 receptor-mediated Ca2+ mobilization, evoked by Ala5-Galanin (2-11) (#GPG-300). Ca2+ response was detected by measuring aequorin-derived fluorescence following application of human Galanin at different concentrations. The EC50 measured for Ala5-Galanin (2-11) is 4.73 nM.
- Webling K. et al. (2016) Neuropeptides 60, 75.
- Liu, M. et al. (2013) PLoS One 8, e63473.
Ala5-Galanin (2-11) is a galanin analogue that acts as a potent, selective and specific Galanin 2 receptor (GalR2) agonist. Ala5-Galanin (2-11) is a full agonist of Gal2R with no detectable binding to human galanin receptors 1 and 3. Ala5-Galanin (2-11) is based on the short galanin fragment galanin (2–11) including a single amino acid substitution of alanine instead of serine at position five.
To date, Ala5-Galanin (2-11) is the shortest galanin receptor 2 specific agonist reported1. Ala5-Galanin (2-11) activates GalR2 with an EC50 value of 1.01 ± 0.18 μM1.
Galanin receptors belong to the family of G-protein coupled receptors and consist of three subtypes: GalR1, GalR2, and GalR32.
Ala5-Galanin (2-11) (#GPG-300) is a highly pure, synthetic, and biologically active peptide.
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