Overview
Angiotensin II Receptor Pharmacology Explorer Kit (#EK-405) contains Angiotensin Receptors Type I and II agonists and antagonists, ideal for screening purposes.
Compounds
| Product Name | Cat # | Size |
|---|---|---|
Angiotensin A (1-8) |
SPA-105 | 1 x 5 mg |
[D-Ala7]-Angiotensin I/II (1-7) |
SPA-160 | 1 x 1 mg |
Angiotensin II acetate |
SPA-165 | 1 x 5 mg |
EMD 66684 |
E-160 | 1 x 5 mg |
Novokinin |
SPA-125 | 1 x 1 mg |
PD 123319 ditrifluoroacetate |
P-245 | 1 x 5 mg |
Scientific Background
Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.
Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
- Mukoyama, M. et al. (1993) J. Biol. Chem. 268, 24539.
- De Gasparo, M. et al. (2000) Pharmacol. Rev. 52, 415.
- Carey, R.M. and Siragy, H.M. (2003) Endocr. Rev. 24, 261.
