Overview
Alomone Labs is pleased to offer the Angiotensin II Receptor Premium Research Pack (#ESP-950). The Research Pack contains all you need for angiotensin II receptor research, all in one economical package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody |
AAR-011 | 1 x 0.2 ml |
Angiotensin II Receptor Type-1 (extracellular) Blocking Peptide |
BLP-AR011 | 1 x 40 µg |
Anti-Angiotensin II Receptor Type-2 (extracellular) Antibody |
AAR-012 | 1 x 0.2 ml |
Angiotensin II Receptor Type-2 (extracellular) Blocking Peptide |
BLP-AR012 | 1 x 40 µg |
| Activators/Agonists | ||
Angiotensin A (1-8) |
SPA-105 | 1 x 10 mg |
Angiotensin II acetate |
SPA-165 | 1 x 50 mg |
[D-Ala7]-Angiotensin I/II (1-7) |
SPA-160 | 1 x 10 mg |
Novokinin |
SPA-125 | 1 x 5 mg |
| Blockers/Antagonists | ||
PD 123319 ditrifluoroacetate |
P-245 | 1 x 25 mg |
Scientific Background
Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.
Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
- Mukoyama, M. et al. (1993) J. Biol. Chem. 268, 24539.
- De Gasparo, M. et al. (2000) Pharmacol. Rev. 52, 415.
- Carey, R.M. and Siragy, H.M. (2003) Endocr. Rev. 24, 261.
