Overview
Lyophilized Powder yes
Origin Ryania speciosa.
Source Natural
MW: 475.54
Purity: >98%
Effective concentration 100 µM - 1 mM.
Structure
Chemical name 1H-Pyrrole-2-carboxylic acid, 3a,4,5,6,7,7a,8,8aoctahydro-3a,4,7a,8a-tetrahydroxy-3,5,8-trimethyl-2-(1-methylethyl)-10-oxo-1H-3b,8-(epoxy ethano)cyclopent(a)inden-1-yl ester, (1R-(1-alpha,3a-beta,3b-alpha,4-alpha,5-beta,7a-beta,8-alpha,8a-beta))-.
Molecular formula C25H33NO8.
Activity Anhydroryanodine is a non-active analogue of ryanodine1.
References-Activity
- Sutko, J.L. et al. (1997) Pharmacol. Rev. 49, 53.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility Methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or six months at -20°C.
References - Scientific background
- Elison, C. and Jenden, D.J. (1967) Biochem. Pharmacol. 16, 1347.
- Frank, M. and Sleaton, W.W. (1975) Res. Commun. Chem. Pathol. Pharmacol. 11, 65.
- Campbell, K.P. et al. (1987) J. Biol. Chem. 262, 6460.
- Sutko, J.L. et al. (1997) Pharmacol. Rev. 49, 53.
Scientific background
Ryanodine (#R-500) is a natural alkaloid isolated from the stem and roots of Ryania Speciosa, a shrub that grows in tropical locations in Central and South America. Ryanodine is a modulator of intracellular Ca2+ release channels1.
Ryanodine was found to be a potent paralysis inducer of skeletal and cardiac muscles2 by inhibiting the SR Ca2+ release through direct binding with the high affinity Ryanodine receptor (RyR) Ca2+ channel as a tetrameric complex2,3.
Anhydroryanodine is an anhydrous non-active form of ryanodine obtained by dehydration of ryanodine4. Anhydroryanodine can be used as a negative control for ryanodine activity4.
Lyophilized Powder
Anhydroryanodine (#A-510) is a highly pure, natural, and biologically active compound.
For research purposes only, not for human use
Last Update: 03/01/2024
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