Anti-CACNG1 (extracellular) Antibody

Voltage-gated Ca²⁺ (Ca_V) channels are ubiquitously expressed and function as Ca²⁺conducting pores in the plasma membrane¹. On the basis of their voltage activation properties, the voltage-gated Ca²⁺ channels can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels.². Ca_V channels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca²⁺ flow across the membrane, and the auxiliary subunits α2δ, γ, and β³.

Ca_Vγ subunits inhibit Ca_V channel activity and modulate its activation and inactivation kinetics. Ca_Vγ subunits have little effect on Ca_V channel trafficking⁴. The γ subunit is an integral membrane protein. The γ subunit family consists of at least 8 members, which share a number of common structural features. Each member is predicted to possess four transmembrane domains, with intracellular N- and C-termini. The first extracellular loop contains a highly conserved N-glycosylation site and a pair of conserved cysteine residues⁵.

Ca_Vγ1 is solely expressed in skeletal muscle and associates with the α1S (Ca_V1.1) subunit⁶.

Knockout mice are indeed viable and show no extreme phenotype. It seems that γ1 enhances the inactivation of ER Ca²⁺ release in a voltage-dependent manner⁶.