Anti-CACNG3 Antibody

Voltage-gated Ca²⁺ (Ca_V) channels are ubiquitously expressed and function as Ca²⁺ conducting pores in the plasma membrane¹. Based on their electrophysiological and pharmacological properties, Ca²⁺ channels have traditionally been classified into L, T, N, P/Q, and R types².

L-type calcium channels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca²⁺ flow across the membrane, and the subunits α2δ, γ, and β³.

The γ subunit is an integral membrane protein. The γ family consists of at least 8 members, which share a number of common structural features. Each member is predicted to possess four transmembrane domains, with intracellular N- and C-termini. The first extracellular loop contains a highly conserved N-glycosylation site and a pair of conserved cysteine residues⁵. Ca_Vγ subunits inhibit Ca_V channel activity and modulate its activation and inactivation kinetics. Ca_Vγ subunits have little effect on Ca_V channel trafficking⁴. Ca_Vγ3 mRNAs are only detectable in mouse brain⁶.