Anti-CACNG6 (extracellular) Antibody

The calcium channel voltage-dependent gamma subunit 6 encoded by the CACNG6 gene, encodes an integral membrane protein. Its role is to stabilize the calcium channel during the channels inactive state. This subunit is responsible for decreasing Ca²⁺ currents when it is co-expressed with the low voltage activated Ca²⁺ channel subunit^1,2. 

The calcium channel γ subunits comprise eight members that share a common topology.
This family is divided in three clusters: The first- γ1 and γ6, second γ5 and γ7 and third γ2,3,4,8. 

Ca_Vγ6 protein is predominantly expressed in striated muscle cells. It is also expressed in skeletal and cardiac muscles and slightly in the brain as a separate isoform.

Ca_Vγ6 structure includes four transmembrane domains (TM) with short intracellular N- and C-terminus. The first TM with a specifically motif- GxxxA is critical for Ca_Vγ6 inhibitory function². Phylogenetic analysis has suggested that all γ subunits developed from a single ancestral gene through tandem repeat and chromosome duplication³.

Voltage-dependent calcium channels are important regulators of calcium influx and are important for several physiological processes including- synaptic transmission, muscle contraction, neurogenesis, hormone secretion, cell motility, cell division and development.

Several recent studies have shown a negative correlation of Ca_Vγ6 gene expression to chronic obstructive pulmonary disease, responses of the human airway epithelium following injury and parenchyma in lung tissues^1,3.