Overview
- Peptide CDYENHFNTSKGGEL, corresponding to amino acid residues 401-415 of rat CLCN5 (Accession P51796). Extracellular.
Western blot analysis of rat kidney lysate:1. Anti-CLC-5 Antibody (#ACL-003), (1:200).
2. Anti-CLC-5 Antibody, preincubated with CLC-5 Blocking Peptide (#BLP-CL003).
- Rat kidney sections.
- Jentsch, T.J. et al. (2002) Physiol. Rev. 82, 503.
- Piwon, N. et al. (2000) Nature 408, 369.
CLC5 is a member of the voltage-dependent Cl- channel family that includes nine known members. Based on sequence similarity, CLC5 is closely linked to the CLC3 and CLC4 subunits.
CLC-5 is mainly found in intracellular vesicles, particularly in early endosomes, where it is believed to contribute to their acidification.
The channel is mainly expressed in the kidney, although it has also been found in the small intestine, brain and liver.
Mutations in the CLC5 gene cause Dent's disease, an X-linked renal disorder.
Anti-CLC-5 Antibody (#ACL-003) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize CLC-5 from human, mouse, and rat samples.
Applications
Citations
Powered by Bioz- Hryciw, D.H. et al. (2012) Int. J. Biochem. Cell Biol. 44, 815.
