Anti-mGluR6 (extracellular) Antibody

Glutamate is the principal excitatory neurotransmitter in the central nervous system. It operates through two main classes of receptors: ionotropic receptors (iGluRs), which are ligand-gated ion channels, and metabotropic receptors (mGluRs), which couple to G-proteins to modulate cellular responses via ion channels or intracellular second messengers.

The metabotropic receptors include eight family members (mGluR1-mGluR8) classified into three groups according to their sequence similarities, signal transduction, and agonist selectivity. They all share a common structure, being composed of a single polypeptide with large N-terminal extracellular domain connected through a seven transmembrane domain motif to the intracellular C-terminal tail^1,2. The different mGluR subtypes are localized at both presynaptic and postsynaptic membranes, and are involved in the generation of slow excitatory and inhibitory synaptic potentials, modulation of synaptic transmission, synaptic integration, and plasticity³.

mGluR6 belongs to the third group of metabotrophic glutamate receptors. Its expression in the central nervous system is restricted to retinal rod bipolar cells, and it’s localized to their postsynaptic dendritic membranes^3,4. In the peripheral nervous system, it is also detected in bone marrow stromal cells⁶. mGluR6 inhibits adenylate cyclase, and was shown to inhibit Ca²⁺ influx and nitric oxide synthase activity^3,5,6.