Overview
- Peptide (C)RGLQDAGPRRDTMAD, corresponding to amino acid residues 162 - 176 of mouse NPTXR (Accession Q99J85). Extracellular, C-terminus
- Western blot analysis (1:200-1:600).
Western blot analysis of mouse brain lysate (lanes 1 and 3) and rat brain lysate (lanes 2 and 4):1-2. Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody (#ANR-193), (1:400).
3-4. Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody, preincubated with Neuronal Pentraxin Receptor (NPTXR)(extracellular) Blocking Peptide (BLP-NR193).
Western blot analysis of human SH-SY5Y neuroblastoma cell line lysate (lanes 1 and 3) and human Jurkat T-cell leukemia cell line lysate (lanes 2 and 4):1-2. Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody (#ANR-193), (1:400).
3-4. Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody, preincubated with Neuronal Pentraxin Receptor (NPTXR)(extracellular) Blocking Peptide (BLP-NR193).
Cell surface detection of Neuronal Pentraxin Receptor by indirect flow cytometry in live intact human THP-1 monocytic leukemia cell line:___ Cells.
___ Cells + goat-anti-rabbit-FITC.
___ Cells + Anti-Neuronal Pentraxin Receptor (NPTXR)(extracellular) Antibody (#ANR-193), (5μg) + goat-anti-rabbit-FITC.
Neuronal Pentraxin Receptor (NPTXR) belongs to the Pentraxin superfamily of proteins (NP) that is characterized by a pentraxin domain at the C-terminal end. It is the only pentraxin family member anchored to the cell membrane by a putative N-terminal transmembrane domain, as opposed to the other two family members, Neuronal Pentraxin1 (NP1) and Neuronal Pentraxin 2 (NP2) that are secreted proteins. NPs can form homo pentamers and hetero pentamers via their pentraxin domains 1.
NPTXR was first identified as the receptor for the snake venom toxin taipoxin and was later found to bind to AMPARs at excitatory synapses and play important, roles in the activity-dependent regulation of neural circuits via this binding activity 1.
Lately, the levels of NPTXR protein in cerebrospinal fluid has been identified as a novel potential biomarker of Alzheimer’s disease progression and could have important utility in assessing treatment success in clinical trials 2. In addition, NPTXR was identified as a molecule required for gastric cancer metastasis 3.
