Anti-SLC25A18 (GC2) Antibody

The solute carrier family 25 member 18 (SLC25A18) is one of the mitochondrial glutamate carriers within the SLC25 family, also known as the mitochondrial carrier family (MCF). Alongside SLC25A22, which shares similar structural and functional properties, SLC25A18 facilitates the transport of glutamate across the mitochondrial inner membrane by functioning as a symporter, coupling glutamate transport with proton movement to maintain mitochondrial pH and ionic balance^1,3.

SLC25A18 is predominantly expressed in the brain, liver, and testis, with comparatively lower levels in tissues like the breast, lung, and colon^2,3. Its tissue-specific expression aligns with its functional role in nitrogen metabolism and the aspartate-glutamate shuttle, which connects mitochondrial and cytosolic processes critical for energy production and amino acid metabolism^1,3.

Biological processes involving SLC25A18 include energy metabolism and regulation of the Warburg effect. For instance, in colorectal cancer (CRC), SLC25A18 inhibits the Warburg effect and reduces cell proliferation via the Wnt/β-catenin pathway². In Alzheimer’s disease (AD), elevated SLC25A18 expression contributes to mitochondrial dysfunction and neuronal apoptosis, emphasizing its role in neurodegeneration^4,5. These processes highlight the significance of maintaining proper SLC25A18 activity for cellular homeostasis.

Dysregulation of SLC25A18 is associated with conditions such as colorectal cancer and neurodegenerative diseases. Immunodetection of SLC25A18 can benefit research into cancer biology, mitochondrial dysfunction, and neurodegeneration, offering insights into both metabolic and signaling pathways relevant to these diseases.