Overview
- Peptide CSRGPGSGAADGMEE, corresponding to amino acid residues 26-40 of rat SSTR1 (Accession P28646). Extracellular, N-terminus.
Western blot analysis of rat brain lysate:1. Anti-Somatostatin Receptor Type 1 (extracellular) Antibody (#ASR-001), (1:200).
2. Anti-Somatostatin Receptor Type 1 (extracellular) Antibody, preincubated with Somatostatin Receptor Type 1 (extracellular) Blocking Peptide (#BLP-SR001).
- Mouse brain sections (1:400) (Lukomska, A. et al. (2020) Brain Struct. Funct. 225, 387.).
Expression of SSTR1 in rat parietal cortex.Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-Somatostatin Receptor Type 1 (extracellular) Antibody (#ASR-001), (1:1000), followed by goat anti-rabbit-Alexa-488. A. SSTR1 immunoreactivity (green) appears in neuron outlines – mostly axonal and dendritic (arrows). B. Pre-incubation of the antibody with Somatostatin Receptor Type 1 (extracellular) Blocking Peptide (#BLP-SR001), suppressed staining. Cell nuclei are stained with DAPI (blue).
- Hofland, LJ. and Lamberts, S.W. (2001) Ann. Oncol. 12, S31.
- Fombonne, J. et al. (2003) Reprod. Biol. Endocrinol. 1, 19.
- Slooter, G.D. et al. (2001) Br. J. Surg. 88, 31.
- Schulz, S. et al. (2002) Gynecol. Oncol. 84, 235.
Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain it acts as a neurotransmitter in both a stimulatory and inhibitory manner.1,2
Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4 and SSTR5) which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time and tissue-specific manner.2
Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in in vivo imaging of tumors that are positive to somatostatin receptors.4
Anti-Somatostatin Receptor Type 1 (extracellular) Antibody (#ASR-001) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize SSTR1 from rat, mouse, and human samples.
Applications
Citations
Powered by Bioz- Mouse brain sections (1:400).
Lukomska, A. et al. (2020) Brain Struct. Funct. 225, 387.
