Overview
- Peptide (C)GSNQTEPYYDMTSN, corresponding to amino acid residues 30-43 of rat SSTR2 (Accession P30680). Extracellular, N-terminus.
Cell surface detection of Somatostatin Receptor Type 2 in live intact mouse J774 macrophage cells:___ Cells.
___ Cells + rabbit IgG isotype control-FITC (#RIC-001-F).
___ Cells + Anti-Somatostatin Receptor Type 2 (extracellular)-FITC Antibody (#ASR-006-F), (2.5 µg).
Cell surface detection of Somatostatin Receptor Type 2 in live intact human THP1 monocytic leukemia cells:___ Cells.
___ Cells + rabbit IgG isotype control-FITC (#RIC-001-F).
___ Cells + Anti-Somatostatin Receptor Type 2 (extracellular)-FITC Antibody (#ASR-006-F), (2.5 µg).
- Hofland, L.J. and Lamberts, S.W. (2001) Ann. Oncol. 12, S31.
- Fombonne, J. et al. (2003) Rep. Biol. Endocrinol. 1, 19.
- Slooter, G.D. et al. (2001) Br. J. Surg. 88, 31.
- Schulz, S. et al. (2002) Gyn. Oncol. 84, 235.
Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner1,2.
Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes1,2. Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner2.
Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors3. Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors4.
In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.
Anti-Somatostatin Receptor Type 2 (extracellular) Antibody (#ASR-006) is a highly specific antibody directed against an extracellular epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize SSTR2 from mouse, human and rat samples.
Anti-Somatostatin Receptor Type 2 (extracellular)-FITC Antibody (#ASR-006-F) is directly conjugated to fluorescein isothiocyanate (FITC). This labeled antibody can be used in immunofluorescent applications such as direct flow cytometry and live cell imaging.
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