Overview
Alomone Labs is pleased to offer the ASIC1 Channel Basic Research Pack (#ESB-200). The Research Pack contains all you need for ASIC1 channel research: Antibodies recognizing different domains of the channel and a specific ASIC1 blocker and activator, all in one economical package!
Compounds
| Product Name | Cat # | Size |
|---|---|---|
| Antibodies | ||
Anti-ASIC1 Antibody |
ASC-014 | 1 x 0.2 ml |
ASIC1 Blocking Peptide |
BLP-SC014 | 1 x 40 µg |
Anti-pan ASIC (extracellular) Antibody |
ASC-031 | 1 x 0.2 ml |
Pan ASIC (extracellular) Blocking Peptide |
BLP-SC031 | 1 x 40 µg |
| Activators/Agonists | ||
MitTx Toxin |
M-100 | 1 x 10 µg |
| Blockers/Antagonists | ||
Psalmotoxin-1 |
STP-200 | 1 x 0.1 mg |
Scientific Background
ASIC1 is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC2, ASIC3 and ASIC4.
The ASICs are in fact part of a larger superfamily termed epithelial Na+ channels (EnaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N- and C- termini.
There are two recognized splice variants of the ASIC1 gene that differ on their N-termini, ASIC1a and ASIC1b that have different tissue distributions and functions.
The ASIC1 responds to a decrease in extracellular pH with an inward cation current that is quickly inactivated despite the continuous presence of protons in the medium.
Lately, ASIC1 has been implicated in processes such as learning and memory in the central nervous system.
- Kellenberger, S. et al. (2002) Physiol. Rev. 82, 735.
- Wemmie, J. A. et al. (2002) Neuron 34, 463.
- Wemmie, J. A. et al. (2003) J. Neurosci. 23, 5496.
