Bradykinin is a potent effector peptide that binds the bradykinin receptors B₂. Bradykinin reduces blood pressure and increases vascular permeability by inducing smooth muscle relaxation and blood vessel dilation¹.

Bradykinin is one the most potent known factors inducing pain substances that acts on afferent sensory neurons Bradykinin stimulates the synthesis of prostaglandins² and is a major contributor to the innate inflammatory response³. Injection of Bradykinin into the skin produces all the inflammation basic signs⁴. Bradykinin has been implicated also in various shock syndromes⁵. Application of Bradykinin to the central nervous system appears to initiate events leading to neural tissue damage as well as long lasting disturbances affecting blood-brain barrier function⁶.